James Bianco, M.D. is a 30-year veteran of the biopharmaceutical industry. In 1991, Dr. Bianco founded CTI Biopharma, Inc. and from 1992 to 2016 was the Chief Executive Officer of CTI Biopharma. During his tenure at CTI Biopharma, Dr. Bianco was responsible for strategic portfolio development and identifying, acquiring, licensing, purchasing, or acquiring through international merger and acquisition, five drug candidates, four of which have since been approved by the FDA and with three receiving accelerated or conditional regulatory approval in the U.S. and/or E.U. Dr. Bianco was responsible for the purchase of pacritinib, a novel Jak2 inhibitor which was partnered with Baxalta for $60 million upfront and $120 million committed Phase 3 clinical trial related expenses. Dr. Bianco designed and implemented the pacritinib PERSIST-2 phase 3 trial which was the basis for its accelerated approval and the subsequent acquisition of CTI Biopharma by SOBI for $1.75 billion.

Dr. Bianco earned his M.D. from the Mount Sinai Icahn School of Medicine and completed his residency and chief residency at the Mount Sinai Medical Center in New York City. He completed his fellowship in Hematology/Oncology at the University of Washington/Fred Hutchinson Cancer Research Center (FHCRC) where he was appointed Assistant Professor of Medicine, Assistant Member FHCRC and Director of the Bone Marrow Transplant Unit at a “Hutch” affiliate (SVAMC). He is the recipient of numerous awards including the National Organization of Rare Disease award for the development of Trisenox.

Dr. Le Bourdonnec is a seasoned biotech executive with broad scientific and leadership experience across all stages of drug discovery through clinical development and regulatory approval. He has successfully led R&D programs in multiple therapeutic areas including oncology, pain, gastro- intestinal disorders, infectious diseases and neurodegenerative diseases. He is a noted expert on opioid receptor biochemistry and pharmacology and has discovered and developed several drugs targeting various members of the opioid receptor family.

Prior to joining TuHURA, Dr. Le Bourdonnec served as the Chief Scientific Officer and Scientific Advisor for HDAX Therapeutics, a biotechnology company pioneering a novel approach to targeting HDAC6 for the discovery and development of breakthrough therapeutics for high unmet medical needs. During his tenure at HDAX, Dr. Le Bourdonnec was responsible for developing a research strategy and managing discovery activities that contributed to the company’s completion of an oversubscribed seed round in September 2024. Prior to HDAX Therapeutics, he served as VP, Chemical, Pharmaceutical & Pre- Clinical Sciences at Deciphera Pharmaceuticals where he led a team of 31 scientists and managed Medicinal Chemistry, Pharmaceutical Sciences, ADME/DMPK & Toxicology activities supporting the identification of novel kinase inhibitors designed using Deciphera’s proprietary kinase switch control platform. He was also responsible for managing non-clinical development activities for Deciphera’s clinical stage products. Prior to that, he led several R&D functions at Yumanity Therapeutics and contributed to the company’s growth from early start-up to a clinical stage organization. Earlier in his career, Dr. Le Bourdonnec served as the VP, Discovery Chemistry & Pharmaceutical Research at Cubist Pharmaceuticals, where he led a department of 87 chemists (57 internal; 30 external) across different functions including Medicinal Chemistry, Computational Chemistry, Analytical Chemistry, Process Chemistry Research, Formulation Research, Chemistry Outsourcing, Bioinformatics, Cheminformatics, Compound Management and High-Throughput Screening. He began his industry career at Adolor Corporation (acquired by Cubist Pharmaceuticals in Oct 2011) and held a number of positions, culminating as the Senior Director, Program Management and Discovery. During his time at Adolor, he played an integral role in many value-driving accomplishments, including the invention of first-in-class spirocyclic delta opioid receptor (DOR) agonists as potential analgesics (ADL5859 & ADL5747) which were licensed to Pfizer for $30M upfront.

Dr. Le Bourdonnec holds a Chemical Engineering degree and a PhD in Organic Chemistry from the University of Lille (France). He also completed a post-doctoral fellowship in the US in the laboratory of Professor Portoghese at the University of Minnesota.

Mr. O’Neill has over 25 years of clinical trial experience, having led large and small Clinical Operations teams at sponsors (Biotech/Pharma), CROs and research hospitals. As a former cancer patient and survivor of malignant melanoma, Mr. O’Neill is passionate about developing advanced immunotherapies for patients with cancer and other debilitating diseases and is focused on innovative strategies to enhance the clinical trial experience for patients and their care teams. He joins TuHURA having most recently served as Senior Director, Clinical Operations at Cellectis, where he was responsible for clinical trial programs of allogeneic “off-the-shelf” gene-edited CAR T-cell products for the treatment of relapsed or refractory B-cell acute lymphoblastic leukemia and multiple myeloma. Prior to Cellectis, he served in multiple roles, including most recently as Senior Director, Clinical Operations at Incyte, where he helped lead the pivotal trials and subsequent supporting trials that resulted in the marketing approval and label expansion of Jakafi® (ruxolitinib), Incyte’s first approved therapy and the first JAK inhibitor approved by FDA. He also served as the Innovation Lead for Incyte’s Clinical Development Operations organization. Additional appointments over the course of his career include roles at Sanofi, AAI Pharma, and Beth Israel Deaconess Medical Center.

Mr. O’Neill holds a Bachelor of Science in Biology from Fairfield University and a Master of Business Administration in Pharmaceutical and Healthcare Marketing from St. Jospeh’s University – Haub School of Business. He has since received a Leadership & Management Certificate from The Wharton School, and Certificates in Disruptive Strategy and Digital Health from Harvard Business School. Additionally, he was awarded “Emerging Pharma Leader” by Pharmaceutical Executive as a special recognition to rising leaders in the life sciences industry (May 2020 edition of Pharmaceutical Executive magazine).

James Bianco, M.D. is a 30-year veteran of the biopharmaceutical industry. In 1991, Dr. Bianco founded CTI Biopharma, Inc. and from 1992 to 2016 was the Chief Executive Officer of CTI Biopharma. During his tenure at CTI Biopharma, Dr. Bianco was responsible for strategic portfolio development and identifying, acquiring, licensing, purchasing, or acquiring through international merger and acquisition, five drug candidates, four of which have since been approved by the FDA and with three receiving accelerated or conditional regulatory approval in the U.S. and/or E.U. Dr. Bianco was responsible for the purchase of pacritinib, a novel Jak2 inhibitor which was partnered with Baxalta for $60 million upfront and $120 million committed Phase 3 clinical trial related expenses. Dr. Bianco designed and implemented the pacritinib PERSIST-2 phase 3 trial which was the basis for its accelerated approval and the subsequent acquisition of CTI Biopharma by SOBI for $1.75 billion.

Dr. Bianco earned his M.D. from the Mount Sinai Icahn School of Medicine and completed his residency and chief residency at the Mount Sinai Medical Center in New York City. He completed his fellowship in Hematology/Oncology at the University of Washington/Fred Hutchinson Cancer Research Center (FHCRC) where he was appointed Assistant Professor of Medicine, Assistant Member FHCRC and Director of the Bone Marrow Transplant Unit at a “Hutch” affiliate (SVAMC). He is the recipient of numerous awards including the National Organization of Rare Disease award for the development of Trisenox.

Mr. O’Neill has over 25 years of clinical trial experience, having led large and small Clinical Operations teams at sponsors (Biotech/Pharma), CROs and research hospitals. As a former cancer patient and survivor of malignant melanoma, Mr. O’Neill is passionate about developing advanced immunotherapies for patients with cancer and other debilitating diseases and is focused on innovative strategies to enhance the clinical trial experience for patients and their care teams. He joins TuHURA having most recently served as Senior Director, Clinical Operations at Cellectis, where he was responsible for clinical trial programs of allogeneic “off-the-shelf” gene-edited CAR T-cell products for the treatment of relapsed or refractory B-cell acute lymphoblastic leukemia and multiple myeloma. Prior to Cellectis, he served in multiple roles, including most recently as Senior Director, Clinical Operations at Incyte, where he helped lead the pivotal trials and subsequent supporting trials that resulted in the marketing approval and label expansion of Jakafi® (ruxolitinib), Incyte’s first approved therapy and the first JAK inhibitor approved by FDA. He also served as the Innovation Lead for Incyte’s Clinical Development Operations organization. Additional appointments over the course of his career include roles at Sanofi, AAI Pharma, and Beth Israel Deaconess Medical Center.

Mr. O’Neill holds a Bachelor of Science in Biology from Fairfield University and a Master of Business Administration in Pharmaceutical and Healthcare Marketing from St. Jospeh’s University – Haub School of Business. He has since received a Leadership & Management Certificate from The Wharton School, and Certificates in Disruptive Strategy and Digital Health from Harvard Business School. Additionally, he was awarded “Emerging Pharma Leader” by Pharmaceutical Executive as a special recognition to rising leaders in the life sciences industry (May 2020 edition of Pharmaceutical Executive magazine).

Dr. Le Bourdonnec is a seasoned biotech executive with broad scientific and leadership experience across all stages of drug discovery through clinical development and regulatory approval. He has successfully led R&D programs in multiple therapeutic areas including oncology, pain, gastro- intestinal disorders, infectious diseases and neurodegenerative diseases. He is a noted expert on opioid receptor biochemistry and pharmacology and has discovered and developed several drugs targeting various members of the opioid receptor family.

Prior to joining TuHURA, Dr. Le Bourdonnec served as the Chief Scientific Officer and Scientific Advisor for HDAX Therapeutics, a biotechnology company pioneering a novel approach to targeting HDAC6 for the discovery and development of breakthrough therapeutics for high unmet medical needs. During his tenure at HDAX, Dr. Le Bourdonnec was responsible for developing a research strategy and managing discovery activities that contributed to the company’s completion of an oversubscribed seed round in September 2024. Prior to HDAX Therapeutics, he served as VP, Chemical, Pharmaceutical & Pre- Clinical Sciences at Deciphera Pharmaceuticals where he led a team of 31 scientists and managed Medicinal Chemistry, Pharmaceutical Sciences, ADME/DMPK & Toxicology activities supporting the identification of novel kinase inhibitors designed using Deciphera’s proprietary kinase switch control platform. He was also responsible for managing non-clinical development activities for Deciphera’s clinical stage products. Prior to that, he led several R&D functions at Yumanity Therapeutics and contributed to the company’s growth from early start-up to a clinical stage organization. Earlier in his career, Dr. Le Bourdonnec served as the VP, Discovery Chemistry & Pharmaceutical Research at Cubist Pharmaceuticals, where he led a department of 87 chemists (57 internal; 30 external) across different functions including Medicinal Chemistry, Computational Chemistry, Analytical Chemistry, Process Chemistry Research, Formulation Research, Chemistry Outsourcing, Bioinformatics, Cheminformatics, Compound Management and High-Throughput Screening. He began his industry career at Adolor Corporation (acquired by Cubist Pharmaceuticals in Oct 2011) and held a number of positions, culminating as the Senior Director, Program Management and Discovery. During his time at Adolor, he played an integral role in many value-driving accomplishments, including the invention of first-in-class spirocyclic delta opioid receptor (DOR) agonists as potential analgesics (ADL5859 & ADL5747) which were licensed to Pfizer for $30M upfront.

Dr. Le Bourdonnec holds a Chemical Engineering degree and a PhD in Organic Chemistry from the University of Lille (France). He also completed a post-doctoral fellowship in the US in the laboratory of Professor Portoghese at the University of Minnesota.

Mr. Krsulich has established diverse international expertise supporting progression of therapies from clinical development through commercialization and leading GxP Quality oversight. Mr. Krsulich joins TuHURA having most recently served as Vice President, Global Quality Assurance (CRO) at Reaction Biology Corporation, an industry-leading provider of drug discovery and development services where he led the global quality team ensuring compliance, designed and implemented a global quality management strategy for all sites across the US and EU and implemented a global quality management system and risk management program. Prior to that, Mr. Krsulich served as Senior Director, GxP Quality Assurance (Gene Therapy) at Renovacor, Inc. (acquired by Rocket Pharmaceuticals). Other career appointments include Senior Director, Quality Assurance GMP (small molecule) at Galera Therapeutics, Inc.; Associate Director, R&D Quality Assurance (small / large molecule, biosimilars) at Teva Pharmaceuticals Industries, where he led the GMP QA activities for Teva’s first commercially approved biologic (AJOVY® – fremanezumab-vfrm); Senior Manager, Development Quality Assurance (small/large molecule, ADC) at Eisai, Inc.; Quality Site Lead (large molecule) at OPK Biotech, LLC.; and Quality Assurance Specialist Team Leader (medical device, biomaterials) at Global Medical, Inc.

Mr. Krsulich holds a Bachelor of Science in Psychology from the University of Pittsburgh. He is also a member of the American Society for Quality.